№2, 2016 (June)

Experience in quality management system development, gradual introduction and certification at the FGBU SSC FMBC named after A.I. Burnasyan at the laboratory of «Meteorological research and standardization».

Year: 2016 (June) Number: №2 Pages: 9-12

Heading: Medical sciences.

Article type: Scientific article.

Authors: Yu.S. Stepanov, N.A. Bogdanenko, K.L. Vikhornov, L.S. Danilochkina, N.N. Dobritskaya.

Organization: FGBU GNC FMBC the name of A.I. Burnasyan, Moscow; VNIIS, expert; Research Administration at FMBA, Moscow, Russia.

Annotation:

The article briefly describes various advantages of the introduced quality management system, presents the QMS development steps and order and becomes a visual guide for other laboratories. The article also lists the problems encountered by the laboratory staff in the QMS development and implementation process.

Keywords:

Quality management system, certification, accreditation, quality.

Content algorithms applied for detection of coexisting occupational diseases caused by noxious agents on the example of cohort patients who were exposed to ionizing radiation.

Year: 2016 (June) Number: №2 Pages: 13-24

Heading: Medical sciences.

Article type: Scientific article.

Authors: A.P. Biryukov, S.M. Dumansky.

Organization: Federal State Budgetary Institution, State Research Center — Federal Medical Biophysical Center named by A.I. Burnazyan.

Annotation:

The article describes methods of detection coexisting occupational diseases caused by noxious agents with the help of mining association rules on the example of cohort patients who were exposed by ionizing radiation. Results were implemented by using Microsoft SQL Server Data Mining environment. The source of information is the database (DB), which was formed in Federal State Budgetary Institution, State Research Center-Federal Medical Biophysical Center named by A.I. Burnazyan and based on case histories of patients who were treated in the hospital for 40 years for the period from 1947 to 1987. It is presented the structure of the information-analytical model which is assigned to capture the typical characteristic combination forms of human diseases caused by various types of harmful factors.

Keywords:

Microsoft Association Rules algorithm, Apriori algorithm, Data Mining, Comorbidity, occupational disease.

Cost-efficiency of Influenza vaccination in working-age population.

Year: 2016 (June) Number: №2 Pages: 25-29

Heading: Medical sciences.

Article type: Scientific article.

Authors: A.V. Rudakova, S.M. Kharit, A.N. Uskov, Yu.V. Lobzin.

Organization: Research institute of children’s infections, St. Petersburg.

Annotation:

Vaccination against influenza virus in children, elderly and working-age population, of high risk groups, is included into the National Immunization Program Schedule. Study objective: to assess the cost efficiency of influenza vaccination in working-age adults, who are not in risk groups and yet experience an occupational hazard in the workplace. Materials and methods: The analysis was carried out on a simulation model, considering the so-ciety perspective, the country epidemiology and farmacoepidemiologi within 1 year horizon. Results: Vaccination of 1000 citizens of working-age against influenza provides prevention of 51 cases of influenza (including, 0.22 cases with a lethal outcome). Thus vaccination will allow to reduce the budgetary costs by 104.7 thousand rubles. The sensitivity analysis showed rather high reliability of the received results. Conclusions: Vaccination against influenza, uptaken by the working-age adults, who experience an occupational hazard in the workplace, is not only clinically, but also economically effective and allows to cut the budget expenses caused by incidence of influenza. Thus in each case it is necessary to consider the local influenza epidemic forecast in each particular city.

Keywords:

Influenza, vaccination, cost-efficiency.

Challenges of the XXI century and approaches to improving mental health services to people working at enterprises subject to medical and sanitary support from the federal medical biological agency.

Year: 2016 (June) Number: №2 Pages: 30-36

Heading: Medical sciences.

Article type: Scientific article.

Authors: V.L. Filippov, Yu.V. Filippova.

Organization: Research Institute of Hygiene, Occupational Pathology and Human Ecology Federal State Unitary Enterprise, Federal Medical Biological Agency, St. Petersburg, Russia.

Annotation:

The problem of mental health of people working in extreme conditions and ways to improve the managerial and methodical approaches to complex assessment of mental health in the context of challenges of the XXI century are considered. A system of managerial and scientific and practical measures for the realization of state policy in the medical, phychological, psychiatric, and social protection of people is presented. The need in creating an up-to-date system of early diagnostics and mental hygiene and mental health prevention for people working in extreme conditions is substantiated.

Keywords:

Mental health, workers, extreme working conditions, toxic chemical substances.

Mental disorders in elderly people receiving medical treatment at a multidisciplinary hospital.

Year: 2016 (June) Number: №2 Pages: 37-44

Heading: Medical sciences.

Article type: Scientific article.

Authors: D.D. Fedotov, V.S. Sheshenin, Yu.I. Polischuk, V.A. Varentsova.

Organization: Center for Mental Health and Rehabilitation, Clinical Hospital № 85 of the Federal Medical and Biological Agency; Federal State Budgetary Scientific Institution «Mental Health Research Centre»; Federal Medical Research Centre of Psychiatry and Addiction Ministry of Health of the Russian Federation.

Annotation:

This work presents published data as well as results of own research and summarizes the experience gained at the psychosomatic department and psychiatrists consultancy provided at the multidisciplinary hospital. It analyses clinical and epidemiologic evidences. It also indicates that many elderly patients suffer from depression and cognitive impairments. The work shows the diversity of psychopathological symptoms in advanced forms of depression in elderly and their relation to cognitive impairments. The combination of depression, anxiety, hypochondria and diverse somatic pathologies causes difficulties for diagnosis. The treatment options are being considered. The work demonstrates general polypharmacotherapy expediency for such patients.

Keywords:

Elderly, depression, cognitive impairment, psychopharmacotherapy, gerontopsychiatry.

Features of clostridial collagenase’ biotechnology – emerging enzymes for medical application.

Year: 2016 (June) Number: №2 Pages: 45-57

Heading: Medical sciences.

Article type: Scientific article.

Authors: A.D. Konon, S.V. Petrovskiy, M.Yu. Shamburova, A.V. Uvarova, Yu.O. Kozlova, M.V. Grigoryeva, B.V. Moskvichev.

Organization: Federal State Unitary Enterprise (FSUE) «Saint Petersburg Research Institute of Vaccines and Sera & Enterprise for Production of Bacterial Preparations» of the Federal Medico-Biological Agency St. Petersburg, Russia.

Annotation:

The breakthrough in the treatment of scar formation, such as Dupuytren’s contracture and Peyronie’s disease may become an application of of Clostridium histolyticum collagenase. General description of clostridial collagenase is presented in review. Reviewed and analysed published data on Clostridium biothinthesis on traditional media of an animal origin. Our own experimental Clostridium cultivation we conducted in various media: -plant peptone, -yeast extract, -fish gelatin. The obtained results way be important for the upgrade in existing microbial collagenase technology.

Keywords:

Collagenase, Clostridium, growing medium, plant peptone, cicatrical formation.

Fitomelanin – preparation to stimulate reproductive activity of male mice.

Year: 2016 (June) Number: №2 Pages: 58-63

Heading: Medical sciences.

Article type: Scientific article.

Authors: A.A. Ivanov, T.M. Bulinina, D.M. Utina, A.V. Odintzov, A.Ju. Bushmanov.

Organization: A.I. Burnazyan Federal Medical and Biophysical Center, Moscow; Institute of Biomedical Problems, Russian Academy of Sciences, Moscow; Joint Institute for Nuclear Research, Dubna; Limited Liability Company «Opus», Irkutsk.

Annotation:

We investigated the possibility of using water-soluble fitomelanin to improve the reproductive activity of intact male mice and restore male reproductive activity, reduced by effects of ionizing radiation. In the experiment, to stimulate the reproductive activity of male mice, they were given a course of melanin in liquid form, orally. The experiment was conducted with fitomelanin with water solubility not less than 80% and the concentration of paramagnetic centers not less than 8×10 17 spin/g, dissolved in the distilled water at an effective concentration. Animals were consuming fitomelanin dissolved in their drinking water, for 8–10 days before the mating and within the mating period. The stimulating effect was achieved in case of a course intake of melanin, in concentration 12.5–50 mg per 100 ml of drinking water, thus increasing the number of animals per litter in intact mice in 1.34 times at and in mice with reproductive activity compromised by radiation exposure – in 1.23 times.

Keywords:

Fitomelanin, mating, reproductive activity, birth, progeny, litter, radiation, mice.

Zika virus disease as a new threat of the 21-st century.

Year: 2016 (June) Number: №2 Pages: 64-72

Heading: Occupational safety and security.

Article type: Scientific article.

Authors: Y.V. Lobzin, I.V. Babachenko.

Organization: Scientific Research Institute of Children’s Infections, Saint-Petersburg.

Annotation:

The article presents a review of the recent epidemiological data, current achievements in the field of Zika virus genetics investigation explaining a widespread circulation of the virus in the world in 2015–2016 time period. There are given the basic clinical manifestations of the disease, laboratory methods of diagnostics used in the world practice and therapy possibilities are described. There are presented the basic recommendations on prevention of Zika fever infection to those who are going to travel to endemic regions or territories of possible population area of the virus vector, mosquitoes from the Aedes genus.

Keywords:

Zika virus disease, epidemiology, mosquitoes Aedes, diagnosis, treatment, prophylaxis.

Health status of Employees working in contact with explosives, at the Defense Industry facilities.

Year: 2016 (June) Number: №2 Pages: 73-79

Heading: Occupational safety and security.

Article type: Scientific article.

Authors: A.R. Tukov, S.M. Shinkarev, A.P. Birukov, V.V. Ivanov, V.A. Dikarev.

Organization: Federal State Budgetary Institution, State Research Center-Federal Medical Biophysical Center named by A.I. Burnazyan, Moscow; Regional Hospital 72 FMBA Russia, Trekhgorny; Сentral Regional Hospital 91 FMBA Russia, Lesnoy.

Annotation:

Purpose to evaluate the morbidity rates among the defense industry employees dealing with explosive materials.This study was based on the information received from the official forms № 01-C approved by the FMBA order dated December 31, 2010 №1125 ‘About report on the medical care provided to the workers of the serviced enterprises’. Statistical analysis of the morbidity rate, the prevalence of morbidity, index of disability among workers of the defense industry dealing with explosive materials has been conducted. We ran a comparative analysis of morbidity rates among employee working in two enter-prises: ‘Electrokhimpribor’ and ‘Priborostroitel’ny zavod’ that had contact with ionizing radiation, along with the employees from the Department №220 at the Electrochemical facility. The morbidity data on various disease and disease forms were collected over the resent five years. Over the observation period for the workers of department №220 at the ‘Electrokhimpribor’ we observed a morbidity rate increase in cardiovascular and digestive system pathology. The largest prevalence in circulatory system diseases had: blood hypertension, and cerebrovascular disease. The frequency o malignant tumors increased in 1.2 times.

The employees of ‘Priborostroitel’ny zavod’ experiencing exposure to IR, had hire frequency of the circulatory system diseases compared to the employees at the Department №220 at ‘Electrokhimpribor’. This is particularly true with respect to the coronary heart disease (increase by a factor of 26.6).

The workers of the two enterprises having contact with ionizing radiation, have a higher incidence of chronic bronchitis (increase by the factor of 17.3), as well as the incidence of peptic ulcer and 12 duodenal ulcer (increase by the factor of 4.4) compared to the workers from department №220 of ‘Electrokhimpribor’.

The workers of the both enterprises common to ionizing radiation exposure, yet employees of the ‘Priborostroitel’ny zavod’ have a higher rate of coronary artery disease (increase by the factor of 1.5) compared to the‘Electrokhimpribor’ employees from the department №220.

Keywords:

Health, explosive materials, defense industry.

Mortality Analysis for the sea and river fleet personnel.

Year: 2016 (June) Number: №2 Pages: 80-90

Heading: Occupational safety and security.

Article type: Scientific article.

Authors: A.A. Abakumov, O.K. Bumay, A.B. Verveda, A.V. Ivanchehko, R.V. Konstantinov, A.E. Sosukin, S.N. Chuprova.

Organization: Federal Medical Biological Agency (FMBA), Moscow; Federal State Unitary Enterprise «Research Institute of Industrial and Marine Medicine Federal Medical Biological Agency (FSUE RI IMM), St. Petersburg; Federal State Budgetary Institution «Research Institute of Children’s Infections Federal Medical Biological Agency» (FSBI RICI FMBA), St. Petersburg.

Annotation:

The mortality of the fleet personnel was studied on the data submitted by the district health centers FMBA for the period from 2000 to 2012. There were analyzed 633 deaths of the sea men of working-age. It was established that the mortality rate for the fleet personnel within the studied period was in 8.9 times less than mortality rate for men of working-age throughout Russia. According to the data from the district medical centers, mortality rate during the voyage was lower, than during the post-voyage period. In the voyage the death has been caused mainly by the cardio-vascular diseases, as for the post-voyage period the death was mainly caused by the neoplastic diseases . On the basis of the obtained data analysis, there were made suggestions for improvement of medical and sanitary service provided to the fleet personnel.

Keywords:

Mortality, fleet personnel, sea and river fleet, medical center.

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