Medicine of Extreme Situations
Scientific and Practical reviewed Journal
of FMBA of Russia

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№2, 2015 (June)

Capabilities and Perspectives of Chronic Hepatitis C Treatment in Children and Adults.

Year: 2015 (June) Number: №2 Pages: 8-16

Heading: Medical sciences.

Article type: Scientific article.

Authors: Yu.V. Lobzin, L.G. Goryacheva, N.V. Rogozina.

Organization: Federal State Budgetary Institution Scientific Research Institute of Pediatric Infectious Deseases, Saint-Petersburg, Russia;
North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg;
Saint-Petersburg State Pediatric Medical University, Saint-Petersburg.

Annotation:

The article consistently presents the stages of the antiviral therapy development used in children and adults with chronic hepatitis C (standard IFN-α, PEG-IFN-α, ribaverin). The main emphasis is on the current state of the problem and on the prospects of the new groups of antiviral drugs – alternatives to the nucleosides, including the latest-generation that are acting at the molecular level. These drugs cause complete inhibition of virus replication and gene expression and they are the most promising antiviral medications.

Keywords:

Chronic hepatitis C, children, interferon, pegylated interferon, PEG-IFN, nucleoside and non-nucleoside NS5B polymerase inhibitors, NS5A inhibitors.

Current issues of social psychiatry and primary psychoprophylaxis of psychosomatic disorders among nuclear industry workers.

Year: 2015 (June) Number: №2 Pages: 17-25

Heading: Medical sciences.

Article type: Scientific article.

Authors: D.D. Fedotov, V.V. Ivanov, Yu.I. Polischuk.

Organization: Center for Mental Health and Rehabilitation, Clinical Hospital № 85 of the Federal Medical and Biological Agency;
Central hospital № 91 of the Federal Medical and Biological Agency;
Federal Medical Research Centre of Psychiatry and Addiction Ministry of Health of the Russian Federation.

Annotation:

Based on data analysis of scientific publications and the results of own observations the authors came to the conclusion that there is a significant prevalence of emotional stress and related psychosomatic disorders among workers of nuclear industry and other industrial enterprises. The broader evidence-based psycho-hygienic and psycho-prophylactic activities in the industry is found to be necessary.

Keywords:

Social psychiatry, mental health, mental hygiene, psycho-prophylaxis, rehabilitation, morbidity, neurotic disorders, depressive disorders, personality disorders, psychosomatic disorders, emotional burnout, periodic medical examinations, psychophysiological monitoring, nuclear industry, professional selection, risk groups.

Parameters of myocardial repolarization in young elite athletes during bicyle exercise test.

Year: 2015 (June) Number: №2 Pages: 26-32

Heading: Medical sciences.

Article type: Scientific article.

Authors: L.M. Makarov, N.N. Fedina, V.N. Komoliatova.

Organization: Center for Syncope and Cardiac Arrhythmias in Children and Adolescents at the Federal Medical Biological Agency, Federal State Budgetary Educational Institution, Central Clinical Children’s Hospital FMBA.

Annotation:

Were evaluated 425 young elite athletes 15-17 years old, members of the young Russian national teams in different sort of sport: basketball (69); baceball (29); water polo (37); volleyball (42); wrestling (35); handball (43); mountain skiing (n=23), rowing (n=21), speed skating (n=8), track and field athletics (n=11), cross-country skiing (n=12), sailing (n=8), swimming (n=4), gymnastics (n=18), boxing (n=37), weightlifting (n=10), soccer (n=29), hockey (n=10). The control group was made by 35 healthy teenagers who aren't involving in competitive sports at the age of 15,5±1,4 years. All subjects were examined by the cardiologist, also were performed 12-channel rest ECG (prone position and standing), EChoCG, bicycle test (PWC 170).

The myocardium repolarization was assessment by microvolt T wave alternans (MMA method) on system Cardiosoft 6.5 V 6.51 2, GE Healthcare, USA. In the outcome of test and at the end of each step of loading, on the 2nd and 4th minutes of recovery the values of absolute (QT) and corrected QT (QTc) intervals were measured manually. QT dynamics (an assessment of parameters of frequency adaptation of an interval of QT to heart rate) was estimated with use of the selective equation of linear regression with an assessment of the slope QT/RR parameter.

The maximum values of an interval of QTc at athletes and in control group didn't exceed 460 ms. For athletes at physical activities were typical more higher values of QT dynamics (steep slope or “hyperadaptation” of QT): slope QT/RR 0,29±0,05 in athletes vs 0,23±0,03 in Control; р < 0,001. It peculiarity can play role in adaptation of cardiovascular system to physical stress and reflect levels of physical working capacity at athletes.

Keywords:

Bicycle test, young elite athletes, QT interval, QT dynamics, microvolt T wave alternans, changes of repolarization.

Clinical and neurophysiologic aspects of critical illness polyneuropathy in children with infectious diseases.

Year: 2015 (June) Number: №2 Pages: 33-37

Heading: Medical sciences.

Article type: Scientific article.

Authors: V.B. Voitenkov, A.A. Vilnits, A.V. Klimkin, N.V. Skripchenko, A.I. Konev, G.P. Ivanova.

Organization: Scientific research Institute of children's infections of federal medical-biological agency of Russia, Saint-Petersburg.

Annotation:

We have examined the status of peripheral nervous system in 26 pediatric patients, admitted to ICU and diagnosed with various infectious diseases. All the patients went through EMG and neurological examination. Some 17 patients were diagnosed with the critical illness polyneuropathy (CIP). CIP symptoms were found on the 5–7 day from the beginning of artificial lung ventilation (AVL), with the most common lesions in peripheral nerves of lower limbs.

Keywords:

Critical illness, critical illness polyneuropathy, critical illness myopathy, children, electromyography.

Urology disease distribution among athletes.

Year: 2015 (June) Number: №2 Pages: 38-42

Heading: Medical sciences.

Article type: Scientific article.

Authors: V.N. Shirshov, D.N. Doronchuk, V.U. Obolonkov, O.K. Shatirishvili, I.M. Konstantinova, U.I. Lebedev, I.M. Charushina.

Organization: Federal Research and Clinical Center of specialized types of medical care and medical technology application FMBA, Moscow.

Annotation:

The study analyzed urological conditions detected in annual medical check-ups carried out from 2009 to 2012, for 654 athletes. The most common pathology in the studied group were: urinary stone disease without clinical manifestations, varicocele and urethritis.

Keywords:

Medical examination athletes, urological morbidity, urolithiasis, varicocele, urethritis.

Vibration stress in high speed winter sports (alpine skiing, ski cross, bobsleigh).

Year: 2015 (June) Number: №2 Pages: 44-51

Heading: Medical sciences.

Article type: Scientific article.

Authors: A.A. Lubyako, A.G. Rusiya, E.M. Solovyova, U.S. Tolstov.

Organization: Federal State Budgetary Interprise «Research and Development Center for Balneology and Rehabilitation» , FMBA, Sochi.

Annotation:

The stud on the frequency of mechanical vibration and physical stress experienced by alpine skiers, ski-cross athletes and bobsleigh racers showed that on the trails, peak stress loads may reach 15g with the frequency of mechanical vibration of 50 Hz. Thus there is a linear dependence between the athlete’s speed on the trail and the intensity of vibration stress. On the basis of the conducted research it is concluded that vibration load is significant, if not primary, part of the extreme physical effects on the body of a professional athlete competing in Alpine skiing, ski cross and bobsleigh. It is also argued that the effect of vibration of the sport equipment units at high physical loads can be considered as etiology of the vibration disease affecting the knee joints, spine, thigh and calf muscles, urogenital system.

Keywords:

Alpine skiing, ski cross, bobsledding, overstress, sport equipment units vibration, vibration disease.

Methodology and system analysis in comprehensive assessment of the baseline health status among population residing in the vicinity of the spaceport «Vostochny», aplicable for further health status monitoring.

Year: 2015 (June) Number: №2 Pages: 53-60

Heading: Occupational safety and security.

Article type: Scientific article.

Authors: V.L. Filippov, V.R. Rembovskiy, Yu.V. Filippova, N.V. Krinitsyn, O.M. Astaf’ev, E.N. Krinitsyna, E.S. Kas’yanenko, I.B. Sivachenko.

Organization: Research Institute of Hygiene, Occupational Pathology and Human Ecology Federal State Unitary Enterprise, Federal Medical Biological Agency of Russia, St. Petersburg.

Annotation:

The paper presents methodology and methods of the comprehensive studies on the baseline health status among population residing in the vicinity of the spaceport «Vostochny», applicable for making a forecast in health status deviations and for situations that call for expert response. The article specifies key features of the conducted mass health examination. The baseline health status comprehensive assessment system, applicable for further health status monitoring, was tested. Materials that regulate management, collection and evaluation of the data on the health status of the population living under conditions of a possible impact of the launch vehicle, were thoroughly analyzed.

Keywords:

Public health, environment, «Vostochny» spaceport.

Voltammetric detection of antibiotics in substances that are subjects to medical control.

Year: 2015 (June) Number: №2 Pages: 62-69

Heading: Occupational safety and security.

Article type: Scientific article.

Authors: E.S. Moiseeva, G.B. Slepchenko, V.A. Fedorchuk.

Organization: Federal State Budgetary Healthcare Institution, Leading Hygiene and Epidemiology Center of the Federal Medical and Biological Agency, Moscow;
Tomsk National Research Polytechnic University, Tomsk Polytechnic University, Tomsk.

Annotation:

Quantum and chemical calculations and mathematical modeling were used to study mechanisms of electrochemical processes on electrodes in an electrochemical cell. Conditions for volammetric determination of some antibiotics were researched and developed.

Keywords:

Voltammetry, drugs, antibiotics, biological environments, electrochemical analysis, quantum and chemical calculations.

Extended FMBA experts meeting on the «Federal Medical and Biological Agency, progress
summary for 2014 and goals set for 2015-2016.»

Year: 2015 (June) Number: №2 Pages: 70

Heading: General information.

Article type: Information article.

Authors: V.V. Uyba.

Organization: Federal Medical and Biological Agency of Russia.

Federal Medical Biological Agency, Grand Panel Resolution from April 21-st, 2015. FMBA 2014 -Annual Resulst, goals for 2015 - 2016.

Year: 2015 (June) Number: №2 Pages: 71-76

Heading: General information.

Article type: Information article.

Authors: V.V. Uyba.

Organization: Federal Medical and Biological Agency of Russia.

Prospects to organize the provision of personalized medical care within the FMBA system.

Year: 2015 (June) Number: №2 Pages: 77-79

Heading: General information.

Article type: Information article.

Authors: V.V. Uyba.

Organization: Federal Medical and Biological Agency of Russia.

Special Design and Engineering Bureau «BIOFIZPRIBOR» 60 years of science and application.

Year: 2015 (June) Number: №2 Pages: 80-83

Heading: General information.

Article type: Information article.

Organization: FSUE SKTB «Biofizpribor» FMBA of Russia.

About co-conducting the 16-th Congress of the Russian Association for the Holter monitoring and Noninvasive ECG (RSHMiNE), 8-th All-Russian Congress on «Clinical Electrocardiology» and 1-st All-Russian Conference on Pediatric Cardiology, FMBA.

Year: 2015 (June) Number: №2 Pages: 84-88

Heading: General information.

Article type: Information article.

Authors: L.M. Makarov, N.N. Fedina, V.N. Komolyatova.

Organization: Center syncope and cardiac arrhythmias in children and adolescents (CSSSA) FMBA of Russia on the basis of FGBUZ CDKB Federal Medical-Biological Agency.

Information report about the 16-th Congress of the International Society for Holter and Noninvasive electrocardiology (ISHNE), 4-6 June 2015, Lyon (France).

Year: 2015 (June) Number: №2 Pages: 89-90

Heading: General information.

Article type: Information article.

Authors: L.M. Makarov, V.N. Komolyatova, N.N. Fedina.

Organization: Center syncope and cardiac arrhythmias in children and adolescents (CSSSA) FMBA of Russia on the basis of FGBUZ CDKB FMBA of Russia.

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